The safety data imply that no laboratory or cardiac monitoring is necessary with this drug. ASH is taking place at the Georgia World Congress Center in Atlanta and virtually from December 11-14, 2021. Tecvayli appeared well tolerated. Talquetamab: New drug may offer hope for those with hard-to-treat blood How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, A safer blood thinner? 2022 Dec 15;387(24):2287-2290. doi: 10.1056/NEJMe2208708. with 5 months after I stopped, I recovered my sense of taste. The study enrolled a total of 288 patients who were unable to tolerate existing therapies or who experienced disease progression after at least three multiple myeloma therapies. The Phase 1 data was published in The New England Journal of Medicine. All participants had received at least three prior treatments, including other types of drugs. The response rate observed in this cohort, which Dr. Chari explained is higher than that of most currently accessible therapies, suggests talquetamab could offer a viable option for patients with relapsed or refractory myeloma, offering a chance to . These are patients whove had typically five lines of therapy over several years. As part of CancerNetworks Face-Off video series, Sikander Ailawadhi, MD, professor of medicine in the Division of Hematology/Oncology at the Mayo Clinic, Jacksonville, Florida, discussed results from the phase 1/2 MonumenTAL-1 trial (NCT04634552), designed to investigate talquetamab in heavily pretreated patients with relapsed/refractory multiple myeloma. Is the ketogenic diet right for autoimmune conditions? Oral TEAEs were common in the trial with 57.9% of patients (n = 44) experiencing a grade 1 or 2 oral AE. You? [] [I]t really is a game-changing paradigm, said Dr. Chari. Taltz Side Effects: Common, Severe, Long Term - Drugs.com Patients enrolled in MomumenTAL-1 were assigned to a dose level and either the subcutaneous (n = 24; 31.6%) or intravenous (IV) dosing cohort (n = 52; 68.4%). In addition, several other studies are underway to assess the use of talquetamab in combination with other existing and investigational multiple myeloma therapies, which could allow patients to have similar or improved benefits, potentially in earlier stages of treatment. For full disclosures of the study authors, visit ash.confex.com.
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